 William Hurt as a character Prof. John Robinson | William Hurt also starred in the next movies:- "Dark City" in a role of Inspector Frank Bumstead;
- "Artificial Intelligence: AI" in a role of Prof. Hobby, the Visionary;
- "Michael" in a role of Frank Quinlan;
- "Body Heat" in a role of Ned Racine;
- "The Village" in a role of Edward Walker;
- "A History of Violence" in a role of Richie Cusack;
- "Mr. Brooks" in a role of Marshall;
- "Vantage Point" in a role of President Ashton;
- "Neverwas" in a role of Dr. Peter Reed;
- "The Incredible Hulk" in a role of Gen. Thaddeus 'Thunderbolt' Ross;
- "The Miracle Maker" in a role of Jairus;
- "Hunt for Justice" in a role of General Mortimer;
- "One True Thing" in a role of George Gulden;
- "Until the End of the World" in a role of Sam Farber, alias Trevor McPhee;
- "Endgame" in a role of Professor Will Esterhuyse;
- "The Countess" in a role of Gyorgy Thurzo;
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 Mimi Rogers as a character Dr. Maureen Robinson | Mimi Rogers also starred in the next movies:- "Dumb and Dumberer: When Harry Met Lloyd" in a role of Mrs. Dunne;
- "Austin Powers: International Man of Mystery" in a role of Mrs. Kensington;
- "Desperate Hours" in a role of Nora Cornell;
- "The Gunman" in a role of Eve Richards;
- "Frozen Kiss" in a role of Gayle;
- "Falling Up" in a role of Meredith;
- "Cruel Intentions 2" in a role of Tiffany Merteuil;
- "Order of Chaos" in a role of Miss Craig;
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 Lacey Chabert as a character Penny Robinson | Lacey Chabert also starred in the next movies:- "Daddy Day Care" in a role of Jenny;
- "Mean Girls" in a role of Gretchen Wieners;
- "Tart" in a role of Eloise Logan;
- "Black Christmas" in a role of Dana Mathis;
- "Bratz: Genie magic" in a role of Kaycee Smith;
- "Sherman's Way" in a role of Marcy;
- "Nice Guys" in a role of Cindy;
- "The Wild Thornberrys Movie" in a role of Eliza Thornberry;
- "An American Tail: The Treasure of Manhattan Island" in a role of Tanya;
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 Heather Graham as a character Dr. Judy Robinson | Heather Graham also starred in the next movies:- "Killing Me Softly";
- "Austin Powers: The Spy Who Shagged Me" in a role of Felicity Shagwell;
- "Bowfinger" in a role of Daisy;
- "Blessed" in a role of Samantha Howard;
- "Sidewalks of New York" in a role of Annie Matthews;
- "Boogie Nights" in a role of Rollergirl/Brandy;
- "Swingers" in a role of Lorraine;
- "Miss Conception" in a role of Georgina;
- "Adrift in Manhattan" in a role of Rose Phipps;
- "From Hell" in a role of Mary Kelly;
- "ExTerminators" in a role of Alex;
- "Hope Springs" in a role of Mandy;
- "License to Drive" in a role of Mercedes Lane;
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 Jack Johnson as a character Will Robinson | Jack Johnson also starred in the next movies:- "Cass" in a role of Young Freeman;
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 Gary Oldman as a character Dr. Zachary Smith | Gary Oldman also starred in the next movies:- "Leon (Professional, The)" in a role of Stansfield;
- "Interstate 60" in a role of O.W. Grant;
- "Hannibal" in a role of Mason Verger;
- "The Fifth Element" in a role of Jean-Baptiste Emanuel Zorg;
- "Harry Potter and the Prisoner of Azkaban" in a role of Sirius Black;
- "The Firm" in a role of Bex Bissell;
- "Batman Begins" in a role of Jim Gordon;
- "Air Force One" in a role of Ivan Korshunov;
- "Dracula" in a role of Dracula;
- "Harry Potter and the Order of the Phoenix" in a role of Sirius Black;
- "Murder in the First" in a role of Milton Glenn;
- "True Romance" in a role of Drexl Spivey;
- "The Contender" in a role of Rep. Sheldon Runyon;
- "The Dark Knight" in a role of Lt. James Gordon;
- "The Backwoods" in a role of Paul;
- "Romeo Is Bleeding" in a role of Jack;
- "Immortal Beloved" in a role of Ludwig van Beethoven;
- "The Unborn" in a role of Rabbi Sendak;
- "Planet 51" in a role of General Grawl;
- "Sid and Nancy" in a role of Sid Vicious;
- "The Book of Eli" in a role of Carnegie;
- "Rain Fall" in a role of Holtzer;
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 Matt LeBlanc as a character Maj. Don West | Matt LeBlanc also starred in the next movies:- "Charlie's Angels" in a role of Jason Gibbons;
- "Charlie's Angels: Full Throttle" in a role of Jason;
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 Jared Harris as a character Older Will Robinson | Jared Harris also starred in the next movies:- "Mr. Deeds" in a role of Mac McGrath;
- "Resident Evil: Apocalypse" in a role of Dr. Ashford;
- "Sylvia" in a role of Al Alvarez;
- "How to Kill Your Neighbor's Dog" in a role of False Peter;
- "Igby Goes Down" in a role of Russel;
- "Lady in the Water" in a role of Goatee Smoker;
- "From Within" in a role of Bernard;
- "Tales of the Black Freighter" in a role of Ridley;
- "Far and Away" in a role of Paddy;
- "Extraordinary Measures" in a role of Webber;
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 Mark Goddard as a character General | Mark Goddard starred only in the movie "Lost in Space" |
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 Lennie James as a character Jeb Walker | Lennie James also starred in the next movies:- "Snatch." in a role of Sol;
- "Sahara";
- "Outlaw" in a role of Cedric Munroe;
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 Marta Kristen as a character Reporter #1 | Marta Kristen starred only in the movie "Lost in Space" |
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 June Lockhart as a character Principal Cartwright | June Lockhart also starred in the next movies:- "Strange Invaders" in a role of Mrs. Bigelow;
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 Edward Fox as a character Businessman | Edward Fox also starred in the next movies:- "Anastasia: The Mystery of Anna" in a role of Dr. Hauser;
- "A Hazard of Hearts" in a role of Lord Harry Wrotham;
- "Force 10 from Navarone" in a role of SSgt. Dusty Miller;
- "The Bounty" in a role of Captain Greetham;
- "Gandhi" in a role of Gen. Reginald Dyer;
- "The Importance of Being Earnest" in a role of Lane, Algy's Butler;
- "The Go-Between" in a role of Hugh Trimingham;
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 Adam Sims as a character Lab Technician | Adam Sims starred only in the movie "Lost in Space" |
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 Angela Cartwright as a character Reporter #2 | Angela Cartwright starred only in the movie "Lost in Space" |
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