Cheech Marin as a character Pedro De Pacas | Cheech Marin also starred in the next movies:- "Once Upon a Time in Mexico" in a role of Belini;
- "From Dusk Till Dawn" in a role of Border Guard/Chet Pussy/Carlos;
- "Desperado" in a role of Short Bartender;
- "Christmas with the Kranks" in a role of Officer Salino;
- "FernGully: The Last Rainforest" in a role of Stump;
- "Masked and Anonymous" in a role of Prospero;
- "Cars" in a role of Ramone;
- "The Lion King 1½" in a role of Banzai;
- "Tin Cup" in a role of Romeo Posar;
- "Beverly Hills Chihuahua";
- "Born in East L.A." in a role of Rudy;
- "Oliver & Company" in a role of Tito;
- "The Lion King" in a role of Banzai;
- "Still Smokin" in a role of Cheech;
- "Paulie" in a role of Ignacio;
- "Cheech & Chong's The Corsican Brothers" in a role of Corsican Brother;
- "Spy Kids" in a role of Felix Gumm;
- "Spy Kids 2: Island of Lost Dreams" in a role of Felix Gumm;
- "Yellowbeard" in a role of El Segundo;
- "Hey Watch This";
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Tommy Chong as a character Anthony 'Man' Stoner | Tommy Chong also starred in the next movies:- "FernGully: The Last Rainforest" in a role of Root;
- "Evil Bong" in a role of Jimbo Leary;
- "Half Baked" in a role of Squirrel Master;
- "Still Smokin" in a role of Chong;
- "Cheech & Chong's The Corsican Brothers" in a role of Corsican Brother;
- "Yellowbeard" in a role of El Nebuloso;
- "Hey Watch This";
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Strother Martin as a character Arnold Stoner | Strother Martin also starred in the next movies:- "Butch Cassidy and the Sundance Kid" in a role of Percy Garris;
- "The Wild Bunch" in a role of Coffer;
- "Cool Hand Luke" in a role of Captain;
- "Harper" in a role of Claude;
- "Slap Shot" in a role of Joe McGrath;
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Edie Adams as a character Mrs. Tempest Stoner | Edie Adams also starred in the next movies:- "It's a Mad Mad Mad Mad World" in a role of Monica Crump;
- "The Apartment" in a role of Miss Olsen;
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Harold Fong as a character Chauffeur | Harold Fong starred only in the movie "Up in Smoke" |
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Richard Novo as a character Richard | Richard Novo starred only in the movie "Up in Smoke" |
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Jane Moder as a character Jail Bait | Jane Moder starred only in the movie "Up in Smoke" |
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Pam Bille as a character Jail Bait | Pam Bille starred only in the movie "Up in Smoke" |
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Arthur Roberts as a character Arresting Officer | Arthur Roberts also starred in the next movies:- "The Prophet" in a role of Richard;
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Marian Beeler as a character Judge Gladys Dykes | Marian Beeler starred only in the movie "Up in Smoke" |
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Donald Hotton as a character Bailiff | Donald Hotton also starred in the next movies:- "The Hearse" in a role of Reverend Winston;
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John Ian Jacobs as a character Prosecuting Attorney | John Ian Jacobs starred only in the movie "Up in Smoke" |
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Christopher Joy as a character Curtis | Christopher Joy starred only in the movie "Up in Smoke" |
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Ray Vitte as a character James | Ray Vitte starred only in the movie "Up in Smoke" |
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Michael Caldwell as a character Duane | Michael Caldwell starred only in the movie "Up in Smoke" |
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