 Steve Carell as a character Dan Burns | Steve Carell also starred in the next movies:- "Bruce Almighty" in a role of Evan Baxter;
- "Anchorman: The Legend of Ron Burgundy" in a role of Brick Tamland;
- "Curly Sue" in a role of Tesio;
- "Bewitched" in a role of Uncle Arthur;
- "Little Miss Sunshine" in a role of Frank;
- "Over the Hedge" in a role of Hammy;
- "Evan Almighty" in a role of Evan Baxter;
- "Knocked Up" in a role of Himself;
- "Horton Hears a Who!" in a role of The Mayor of Who-ville;
- "The 40 Year Old Virgin" in a role of Andy Stitzer;
- "Get Smart" in a role of Maxwell Smart;
- "Sleepover" in a role of Officer Sherman;
- "Date Night" in a role of Phil Foster;
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 Juliette Binoche as a character Marie | Juliette Binoche also starred in the next movies:- "Chocolat" in a role of Vianne Rocher;
- "The English Patient" in a role of Hana;
- "Bee Season" in a role of Miriam;
- "Breaking and Entering" in a role of Amira;
- "The Unbearable Lightness of Being" in a role of Tereza;
- "Wuthering Heights" in a role of Catherine Earnshaw;
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 Dane Cook as a character Mitch Burns | Dane Cook also starred in the next movies:- "Torque" in a role of Neil Luff;
- "Farce of the Penguins" in a role of Online Penguin;
- "Waiting..." in a role of Floyd;
- "Good Luck Chuck" in a role of Charlie/Chuck;
- "Mr. Brooks" in a role of Mr. Smith;
- "Horton Hears a Who!";
- "Rough Around the Edges: Live from Madison Square Garden" in a role of Himself;
- "My Best Friend's Girl" in a role of Tank;
- "Dane Cook: Isolated Incident" in a role of Himself;
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 Alison Pill as a character Jane Burns | Alison Pill also starred in the next movies:- "Confessions of a Teenage Drama Queen" in a role of Ella;
- "Milk" in a role of Anne Kronenberg;
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 Brittany Robertson as a character Cara Burns | Brittany Robertson also starred in the next movies:- "Keeping Up with the Steins" in a role of Ashley Grunwald;
- "From Within" in a role of Claire;
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 Marlene Lawston as a character Lilly Burns | Marlene Lawston also starred in the next movies:- "Flightplan" in a role of Julia;
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 Dianne Wiest as a character Nana Burns | Dianne Wiest also starred in the next movies:- "The 10th Kingdom" in a role of The Evil Queen/Christine Lewis;
- "Robots";
- "Practical Magic" in a role of Aunt Bridget 'Jet' Owens;
- "Edward Scissorhands" in a role of Peg;
- "The Lost Boys" in a role of Lucy Emerson;
- "A Guide to Recognizing Your Saints" in a role of Flori;
- "Passengers" in a role of Toni;
- "Falling in Love" in a role of Isabelle;
- "Footloose" in a role of Vi Moore;
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 John Mahoney as a character Poppy Burns | John Mahoney also starred in the next movies:- "The Iron Giant" in a role of General Rogard;
- "In the Line of Fire" in a role of Secret Service Director Sam Campagna;
- "Reality Bites" in a role of Grant Gubler;
- "The Hudsucker Proxy" in a role of Chief Editor Manhattan Argus;
- "Primal Fear" in a role of John Shaughnessy;
- "Antz" in a role of Grebs/Drunk Scout/Additional Voices;
- "Atlantis: The Lost Empire" in a role of Preston B. Whitmore;
- "Say Anything..." in a role of James Court;
- "The Emperor's New Groove 2: Kronk's New Groove" in a role of Papi;
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 Norbert Leo Butz as a character Clay Burns | Norbert Leo Butz starred only in the movie "Dan in Real Life" |
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 Amy Ryan as a character Eileen | Amy Ryan also starred in the next movies:- "Gone Baby Gone" in a role of Helene McCready;
- "Before the Devil Knows You're Dead" in a role of Martha;
- "The Missing Person" in a role of Miss Charley;
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 Jessica Hecht as a character Amy | Jessica Hecht also starred in the next movies:- "The Forgotten" in a role of Eliot;
- "Stay" in a role of Boy's Mother;
- "Sideways" in a role of Victoria;
- "Starting Out in the Evening" in a role of Sandra Bennett;
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 Frank Wood as a character Howard | Frank Wood also starred in the next movies:- "Thirteen Days" in a role of McGeorge Bundy, National Security Advisor;
- "Michael Clayton" in a role of Gerald;
- "Changeling" in a role of Ben Harris;
- "The Missing Person" in a role of Harold Fullmer;
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 Henry Miller as a character Will | Henry Miller starred only in the movie "Dan in Real Life" |
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 Ella Miller as a character Rachel | Ella Miller starred only in the movie "Dan in Real Life" |
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 C.J. Adams as a character Elliott Burns | C.J. Adams starred only in the movie "Dan in Real Life" |
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