 Walter Huston as a character Sam Dodsworth | Walter Huston also starred in the next movies:- "The Treasure of the Sierra Madre" in a role of Howard;
- "And Then There Were None" in a role of Dr. Edward G. Armstrong;
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 Ruth Chatterton as a character Fran Dodsworth | Ruth Chatterton starred only in the movie "Dodsworth" |
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 Paul Lukas as a character Arnold Iselin | Paul Lukas also starred in the next movies:- "The Four Horsemen of the Apocalypse" in a role of Karl von Hartrott;
- "The Lady Vanishes" in a role of Dr. Hartz;
- "20000 Leagues Under the Sea" in a role of Prof. Pierre Arronax;
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 Mary Astor as a character Mrs. Edith Cortright | Mary Astor also starred in the next movies:- "A Kiss Before Dying" in a role of Mrs. Corliss;
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 Kathryn Marlowe as a character Emily Dodsworth McKee | Kathryn Marlowe starred only in the movie "Dodsworth" |
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 David Niven as a character Capt. Clyde Lockert | David Niven also starred in the next movies:- "The Guns of Navarone" in a role of Cpl. Miller;
- "Bonjour tristesse" in a role of Raymond;
- "Death on the Nile" in a role of Colonel Johnny Race;
- "The Charge of the Light Brigade" in a role of Captain James Randall;
- "Bluebeard's Eighth Wife" in a role of Albert De Regnier;
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 Gregory Gaye as a character Baron Kurt Von Obersdorf | Gregory Gaye starred only in the movie "Dodsworth" |
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 Maria Ouspenskaya as a character Baroness Von Obersdorf | Maria Ouspenskaya also starred in the next movies:- "Waterloo Bridge" in a role of Madame Olga Kirowa;
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 Odette Myrtil as a character Renée De Penable | Odette Myrtil starred only in the movie "Dodsworth" |
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 John Payne as a character Harry McKee | John Payne also starred in the next movies:- "Duets" in a role of Houston Sales Guy;
- "The Razor's Edge" in a role of Gray Maturin;
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 Spring Byington as a character Matey Pearson | Spring Byington also starred in the next movies:- "The Charge of the Light Brigade" in a role of Lady Octavia Warrenton;
- "Meet John Doe" in a role of Mrs. Mitchell;
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 Harlan Briggs as a character Tubby Pearson | Harlan Briggs starred only in the movie "Dodsworth" |
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 Bobby Barber as a character Italian taxi driver | Bobby Barber also starred in the next movies:- "Bud Abbott and Lou Costello Meet Frankenstein" in a role of Waiter;
- "Abbott and Costello Meet the Invisible Man" in a role of Sneaky;
- "Abbott and Costello in Who Done It?" in a role of Test Technician in Booth;
- "Bud Abbott and Lou Costello in Hit The Ice" in a role of Candy Butcher - knocked down on Train;
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 John Barclay as a character Guest on ship | John Barclay starred only in the movie "Dodsworth" |
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 Wilson Benge as a character Steward on Queen Mary | Wilson Benge also starred in the next movies:- "The House of Fear" in a role of Guy Davies;
- "Pursuit to Algiers" in a role of Clergyman;
- "The Spider Woman" in a role of Unspecified Clerk;
- "The Pearl of Death" in a role of Second Steward;
- "Scram!" in a role of Hawkins, the Butler;
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